New Pathway That Protects Against Alzheimer's Protein Buildup Found

Senior woman reading a book

Photo by Clément Falize on Unsplash

Based in Miami, Brian Sidman guides BAS Holdings Investments, LLC, where he provides solutions in the areas of real estate acquisition and asset management. With a strong community focus, Brian Sidman previously held responsibilities on the board of a nonprofit foundation that provided financial support to St. Jude Children’s Research Hospital. 

Researchers at the St. Jude Department of Immunology were recently involved in research that yielded a new pathways that prevents Alzheimer's protein buildup. Also enabling the regulation of inflammation, the pathway involves microglial cells that are the central nervous system and brain’s primary immune cell source, and is known as LC3-associated endocytosis (LANDO). 

Activating LANDO can help prevent deposits of the neurotoxic β-amyloid protein and safeguard against neurodegeneration and neuroinflammation, which are tied to memory problems. In addition, inhibiting the pathway may be a strategy for boosting cancer immunotherapy results. 

The study results were described as reflecting a situation where “you never know where science will lead,” as the project was initially focused on immune responses among children against cancer.

ICSC's 2019 Annual RECon Event

Brian A. Sidman, the founder and principal of BAS Holdings Investments, LLC, attends the annual International Council of Shopping Centers (ICSC) RECon conference. ICSC RECon offers professionals like Brian A. Sidman a chance to advance their careers, learn about issues facing the commercial real estate field, and connect with others.

Slated to begin on May 19, the 2019 RECon event will be held at the Las Vegas Convention Center. The first day of this four-day event will include professional development workshops as well as an opening keynote presentation. On the remaining three days of the conference, the event's Leasing Mall, Marketplace Mall, and SPREE will be open, providing attendees with first looks at new products and services for the retail field. The second and third days of the event also include more keynote presentations as well as conference sessions and professional development opportunities.

Past session topics have touched on ways to deal with emergencies and catastrophic events, current issues in commercial real estate, ways to support transitions between online and offline business, and long-term projections for retail operation and related business.